Is Gianotti–Crosti syndrome associated with atopy? A case–control study and a postulation on the intrinsic host factors in Gianotti–Crosti syndrome
Author(s)
Author(s)
Chuh, A.
Zawar, V.
Sciallis, G.
Date Issued
2016
Publisher
John Wiley & Sons
Journal
Pediatric Dermatology
Volume
33
Issue
5
Start page
488
End page
492
Abstract
Objectives
To investigate whether Gianotti–Crosti syndrome (GCS) in children is associated with atopy.
Methods
The setting was two outpatient clinic. Diagnoses of asthma and atopic dermatitis (AD) were made according to internationally accepted diagnostic criteria. Allergic rhinitis, atopic urticaria, and allergic conjunctivitis were diagnosed clinically. Participants were children with GCS diagnosed over the previous 5 years. For any child with GCS, we extracted the record of the subsequent age and sex pair-matched child seen for problems unrelated to the skin as controls.
Results
We retrieved the records of 37 pairs of study and control subjects; 28 (76%) children with GCS and 9 (24%) controls had AD (risk ratio [RR] = 3.11[95% confidence interval {CI} 1.73, 5.73]), 31 (84%) children with GCS and 19 (51%) controls had at least one atopic condition (RR = 1.63 [95% CI 1.13, 2.18]) and 11 (30%) children with GCS and 2 (5%) controls had at least three atopic conditions (RR = 5.50 [95% CI 1.29, 35.35]).
Conclusion
GCS is significantly associated with AD and the presence of atopic conditions.
SFU Affiliated Publication
No
Availability at SFU Library
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