Enhanced replication of R5 HIV-1 isolates in vitro by a small-molecule reagent targeting HIV-1 protease
Author(s)
Author(s)
Wardle, N. J.
Hudson, H. R.
Matthews, R. W.
Nunn, C. M.
Vella, C.
Date Issued
2013
Publisher
Wiley
Journal
ChemMedChem
Volume
8
Issue
5
Start page
719
End page
721
Abstract
Chemical enhancement: Designed to target HIV-1 protease, a novel γ-hydroxyphosphonate has been found to significantly enhance viral replication in a panel of clinically relevant R5 HIV-1 isolates. This unexpected result constitutes the first instance of a small molecule capable of doing this, and it has implications for the preparation and use of R5 isolates in vaccine and drug development.
SFU Affiliated Publication
No
Availability at SFU Library
No database links found.