Synthesis, characterization and comparative study of aminophosphonate chelates of gadolinium(III) ions as magnetic resonance imaging contrast agents
Author(s)
Author(s)
Harding, C. T.
McEwen, A. B.
Sadler, P. J.
Kelly, J. D.
Marriott, J. A.
Date Issued
1994
Publisher
Elsevier
Journal
Polyhedron
Volume
13
Issue
12
Start page
1937
End page
1943
Abstract
Gadolinium(III) complexes of aminophosphonates, including a novel ligand L4H8, have been investigated as potential contrast agents for NMR imaging. Water 1H relaxivities at 10 and 200 MHz were determined and luminescence measurements, on TbIII complexes, allowed the determination of the number of coordinated H2O molecules. The complexes bound strongly to hydroxyapatite, suggesting possible targetting to bone in vivo. This was confirmed by 153Gd tracer studies with the most favourable biodistribution in rats being shown by gadolinium(III) ethylenediamine-N,N,N′,N′-tetrakis(methylenephosphonate).
SFU Affiliated Publication
No
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