An eigen-binding site based method for the analysis of anti-EGFR drug resistance in lung cancer treatment

Author(s)
Wang, Debby Dan
Author(s)
Ma, L.
Zou, B.
Yan, H.
Date Issued
2017
Publisher
IEEE
Journal
IEEE/ACM Transactions on Computational Biology and Bioinformatics
Volume
14
Issue
5
Start page
1187
End page
1194
Abstract
We explore the drug resistance mechanism in non-small cell lung cancer treatment by characterizing the drug-binding site of a protein mutant based on local surface and energy features. These features are transformed to an eigenbinding site space and used for drug resistance level prediction and analysis.
URI
DOI
SFU Affiliated Publication
Yes
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