Synthesis, characterization and anticancer evaluation of novel tri-arm star shaped 1,3,5-triazine hydrazones

Author(s)
Author(s)
Machakanur, S. S.
Patil, B. R.
Badiger, D. S.
Bakale, R. P.
Gudasi, K. B.
Date Issued
2012
Publisher
Elsevier
Journal
Journal of Molecular Structure
Volume
1011
Start page
121
End page
127
Abstract
A series of novel trisubstituted triazine hydrazones [N3C3(-OC6H4-p-CH=N-NH-C(O)-C6H4-p-X)3] (X = H, Br, Cl, F, OH, OCH3, CH3, NO2, NH2) were prepared by a three-fold condensation reaction of 2,4,6-tris(4-formylphenoxy)-1,3,5-triazine with p-substituted benzoic acid hydrazides [NH2-NH-C(O)-C6H4-p-X] with excellent yields. The structures were confirmed by elemental analysis, FT-IR, 1H, 13C, 2D-HSQC NMR and mass spectrometry (MALDI-TOF). These derivatives bearing hydrolysable hydrazone linkages were evaluated for their in vitro antiproliferative activity against the human liver carcinoma cell line (HepG2) and human cervix carcinoma cell line (HeLa).
URI
DOI
SFU Affiliated Publication
No
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