Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats — Comparison with gentiopicroside alone
Author(s)
Author(s)
Wang, C.-H.
Cheng, X.-M.
White, K. N.
Branford-White, C. J.
Wang, Z.-T.
Date Issued
2007
Publisher
Elsevier
Journal
Journal of Pharmaceutical and Biomedical Analysis
Volume
44
Issue
5
Start page
1113
End page
1117
Abstract
The pharmacokinetics and bioavailability of gentiopicroside (GPS), an active component of the Gentian plant species, from orally administered decoctions of Gentianae (DG), or in combination with other plants in the prescription of Longdan Xiegan Tang (LXT), was compared in rats with oral administration of GPS alone, using doses adjusted to deliver equivalent amounts of GPS (150 mg/kg). Changes in plasma levels of GPS following oral administration of GPS or DG could be fitted to a one compartment open model with elimination half times (T(1/2)Ke) of 3.35 ± 0.76 h and 6.21 ± 3.07 h, respectively. Kinetics of plasma GPS following oral administration of LXT could be fitted to a two compartments open model with an elimination half time (T(1/2)β) of 3.83 ± 1.54 h. The bioavailability of GPS from DG was markedly better, and that from LXT markedly worse, compared with GPS alone, as judged by the area under concentration-time curve (AUC) values of 70.0 ± 13.9 μg h/ml (DG), 32.7 ± 12.9 μg h/ml (GPS) and 19.1 ± 5.9 μg h/ml (LXT). The study demonstrates the marked variability in pharmacokinetics and bioavailability of an active component from different herbal preparations.
SFU Affiliated Publication
No
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