Bi-bicyclic and bi-tricyclic compounds from Dendrobium thyrsiflorum
Author(s)
Author(s)
Zhang, G.-N.
Zhong, L.-Y.
Guo, Y.-L.
Zhang, C.-F.
Zhang, M.
Wang, Z.-T.
Xu, L.-S.
Date Issued
2005
Publisher
Elsevier
Journal
Phytochemistry
Volume
66
Issue
10
Start page
1113
End page
1120
Abstract
One bi-bicyclic and two bi-tricyclic derivatives of coumarin–benzofuran, phenanthrene–phenanthrene and phenanthrene–phenanthraquinone, along with seven known compounds, were isolated from stems of Dendrobium thyrsiflorum Rchb.f. (Orchidaceae). On the basis of chemical, NMR (1H, 13C, HMQC, HMBC and NOESY) and mass spectrometry data, their structures were elucidated as denthyrsin [3-(5′,6′-dimethoxybenzofuran-2′-yl)-6,7-dimethoxy-2H-chromen-2-one; 1], denthyrsinol (4,5′-dimethoxy-[1,1′]biphenanthrenyl-2,5,4′,7′-tetraol; 2), and denthyrsinone (7,4′,7′-trihydroxy-2,2′,8′-trimethoxy-[5,1′]biphenanthrenyl-1,4-dione; 3). Compounds 1–3 and denthyrsinin (1,5,7-trimethoxyphenanthrene-2,6-diol; 4) showed significant cytotoxic activities against Hela (13.5, 9.3, 9.9 and 2.7 μM, respectively), K-562 (0.45, 1.6, 6.0 and 2.3 μM, respectively) and MCF-7 (18.1, not tested, 3.5 and 4.8 μM, respectively) cell lines.
SFU Affiliated Publication
No
Availability at SFU Library
No database links found.