Withania somnifera root extract enhances chemotherapy through 'Priming'

Author(s)
Author(s)
Henley, A. B.
Yang, L.
Chuang, K.-L.
Sahuri-Arisoylu, M.
Wu, L.-H.
Bell, J. D.
Date Issued
2017
Publisher
PLOS
Journal
PLOS ONE
Volume
12
Issue
1
Abstract
Withania somnifera extracts are known for their anti-cancerous, anti-inflammatory and antioxidative properties. One of their mechanisms of actions is to modulate mitochondrial function through increasing oxidative stress. Recently ‘priming’ has been suggested as a potential mechanism for enhancing cancer cell death. In this study we demonstrate that ‘priming’, in HT-29 colon cells, with W. somnifera root extract increased the potency of the chemotherapeutic agent cisplatin. We have also showed the W. somnifera root extract enhanced mitochondrial dysfunction and that the underlying mechanism of ‘priming’ was selectively through increased ROS. Moreover, we showed that this effect was not seen in non-cancerous cells.
URI
DOI
SFU Affiliated Publication
No
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