Synthesis, characterization and antiproliferative activity of hexa arm star shaped thiosemicarbazones derived from cyclotriphosphazene core

Bligh, Annie Sim Wan

doi:10.1016/j.ica.2014.06.040

Synthesis, characterization and antiproliferative activity of hexa arm star shaped thiosemicarbazones derived from cyclotriphosphazene core

Author(s)

Bligh, Annie Sim Wan

Date Issued

2014

Publisher

Elsevier

Journal

Inorganica Chimica Acta

Volume

421

Start page

459

End page

464

Abstract

A series of novel hexa-arm star shaped thiosemicarbazones with different substitutions at para positions emanating from cyclotriphosphazene core were prepared with excellent yields. The structure of all the synthesized compounds was confirmed by elemental analysis and spectroscopic methods (FT-IR, ¹H, ¹³C, ³¹P NMR, 2D HSQC and ESI-MS). The compounds were evaluated for their in vitro antiproliferative activity against breast cancer (MCF7) and ovarian cancer (PA-1) cell lines using MTT assay. The newly synthesized compounds exhibited moderate to good activity against the tested cell lines. Among them the halo substituted benzoic thiosemicarbazones were found to be more potent towards anticancer activity.

URI

https://repository.sfu.edu.hk/handle/sfu/1494

DOI

10.1016/j.ica.2014.06.040

SFU Affiliated Publication

No

Availability at SFU Library

No database links found.