Reaction of (C-(6-aminomethyl-pyridin-2-yl)methylamine)chloroplatinum(ii) with nucleosides and its biological activity
Author(s)
Author(s)
Bashall, A.
Garrud, C.
McPartlin, M.
Wardle, N.
White, K.
Padhye, S.
Barve, V.
Kundu, G.
Date Issued
2003
Publisher
Royal Society of Chemistry
Journal
Dalton Transactions
Issue
2
Start page
184
End page
188
Abstract
1 H NMR and LC-ESI-MS studies of the interaction between nucleosides (adenosine, cytidine, guanosine, uridine and thymidine) and a monocation platinum(II) complex [Pt(C-(6-aminomethylpyridin-2-yl)methylamine)Cl]+ (1) shows it forms platinum(II) complexes with A, G and C at pH 6 and with T and U at pH 9. The X-ray structure of 1 as the hydrated chloride salt shows extensive hydrogen bonding. Amongst a series of related complexes 1 shows a strong interaction with DNA, demonstrated by inhibition of binding by the intercalator ethidium bromide, and moderate cytotoxicity. The interaction with nucleosides and the structural data suggest that 1 disrupts the DNA structure by coordinate covalent interaction and hydrogen bonding rather than simple intercalation.
SFU Affiliated Publication
No
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