A new phenanthrene with a spirolactone from Dendrobium chrysanthum and its anti-inflammatory activities
Author(s)
Author(s)
Yang, L.
Qin, L.-H.
Bashall, A.
Zhang, C.-F.
Zhang, M.
Wang, Z.-T.
Xu, L.-S.
Date Issued
2006
Publisher
Elsevier
Journal
Bioorganic & Medicinal Chemistry
Volume
14
Issue
10
Start page
3496
End page
3501
Abstract
Investigation of phenolic patterns from the stems of Dendrobium chrysanthum by HPLC–PDA–MS has led to the isolation of a new phenanthrene derivative with a spirolactone ring, dendrochrysanene (1), that proved to suppress the mRNA level of TNF-α, IL8, IL10, and iNOS in murine peritoneal macrophages. The structure of 1 was characterized on the basis of various NMR (1H, 13C, 1H–1H COSY, HMQC, and HMBC), mass spectrometry, and X-ray crystal diffraction data.
SFU Affiliated Publication
No
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