Bligh, Annie Sim WanAnnie Sim WanBlighPan, X.Smith, E.2021-10-112021-10-112014https://repository.sfu.edu.hk/handle/sfu/1493Fructus Euodiae is used in Traditional Chinese Medicine to treat infection. In this study, four of the quinolone alkaloids isolated from Fructus Euodiae showed activity against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). The minimum inhibitory concentrations (MIC) were 8–128 µg/mL, which were equivalent to or lower than the control antibiotics, oxacillin, erythromycin and tetracycline (MIC ≥128 µg/mL). Among these isolated quinolone alkaloids, evocarpine with a 13 carbon alkenyl chain substituent at position-2 showed the best activity against MRSA. This study has demonstrated the potential of quinolone alkaloids from Fructus Euodiae as anti-MRSA compounds and supports the traditional use of the fruit as a treatment for bacterial infections.enjournal article10.1002/ptr.4987