Bligh, Annie Sim WanAnnie Sim WanBlighWardle, N. J.Hudson, H. R.Matthews, R. W.Nunn, C. M.Vella, C.2021-10-122021-10-122013https://repository.sfu.edu.hk/handle/sfu/1502Chemical enhancement: Designed to target HIV-1 protease, a novel γ-hydroxyphosphonate has been found to significantly enhance viral replication in a panel of clinically relevant R5 HIV-1 isolates. This unexpected result constitutes the first instance of a small molecule capable of doing this, and it has implications for the preparation and use of R5 isolates in vaccine and drug development.enjournal article10.1002/cmdc.201300051