Bligh, Annie Sim WanAnnie Sim WanBlighHarding, C. T.McEwen, A. B.Sadler, P. J.Kelly, J. D.Marriott, J. A.2021-12-212021-12-211994https://repository.sfu.edu.hk/handle/sfu/2095Gadolinium(III) complexes of aminophosphonates, including a novel ligand L⁴H₈, have been investigated as potential contrast agents for NMR imaging. Water ¹H relaxivities at 10 and 200 MHz were determined and luminescence measurements, on Tb^III complexes, allowed the determination of the number of coordinated H₂O molecules. The complexes bound strongly to hydroxyapatite, suggesting possible targetting to bone <i>in vivo</i>. This was confirmed by ¹⁵³Gd tracer studies with the most favourable biodistribution in rats being shown by gadolinium(III) ethylenediamine-N,N,N′,N′-tetrakis(methylenephosphonate).enjournal article10.1016/0277-5387(94)80018-9