Synthesis of novel α-functionalized phosphinic acid derivatives of thiophene and the first crystal structure of an α-hydroxyalkylphosphinate

Bligh, Annie Sim WanAnnie Sim WanBlighMcPartlin, M.Sanganee, M. J.Woodroffe, T. M.Geraldes, C. F. G. C.2021-12-212021-12-211998https://repository.sfu.edu.hk/handle/sfu/2087Reaction of 2,5-diformylthiophene with Ph<sub>2</sub>CHNH<sub>2</sub> and hypophosphorus acid yields novel α-hydroxy- or α-amino-methylphosphinic acid derivatives depending on reaction conditions; the X-ray structure analysis of diphenylmethylammonium 5-formyl-2-thienyl(hydroxy)methylphosphinate provides the first direct structural information on the α-hydroxyalkylphosphinate class of compounds.enSynthesis of novel α-functionalized phosphinic acid derivatives of thiophene and the first crystal structure of an α-hydroxyalkylphosphinatejournal article10.1039/A805189E