Bligh, Annie Sim WanAnnie Sim WanBlighYu, D.-G.Branford-White, C.Williams, G. R.White, K.Zhu, L.-M.Chatterton, N. P.2021-11-122021-11-122011https://repository.sfu.edu.hk/handle/sfu/1711Amphiphilic nanofibers composed of the hydrophilic polymer polyvinylpyrrolidone K60 (PVP) and soybean lecithin were fabricated using an electrospinning process. As a result of the templating and confinement properties of the nanofibers, phosphatidyl choline (PC) liposomes were spontaneously formed through molecular self-assembly when the fibers were added to water. The sizes of the self-assembled liposomes could be manipulated by varying the content of PC in the nanofibers (over the range 9.1–33.3% (w/w) in the present study). The influence of PC on nanofiber formation, and a possible mechanism of templated liposome formation are discussed. This facile and convenient strategy for manipulating molecular self-assembly to synthesize liposomes provides a versatile new approach for the development of novel drug delivery systems and biomaterials.enjournal article10.1039/C1SM05961K