Bligh, Annie Sim WanAnnie Sim WanBlighWardle, N. J.Kalber, T.Bell, J. D.2021-11-122021-11-122011https://repository.sfu.edu.hk/handle/sfu/1714Colchicine is a known tubulin binding agent enabling necrosis in tumors. A novel tubulin-directed DO3A–colchicine conjugate and its Gd(III) complex were prepared from <i>N</i>-deacetylcolchicine, coupling alkaloid and polyaza-alicyclic functions via a peptide coupling methodology. The longitudinal proton relaxivity of the Gd(III) complex in water at 4.7 T is 2.86 mM⁻¹ s⁻¹ and a similar efficacy as colchicine towards ovarian carcinoma cells in vitro.enjournal article10.1016/j.bmcl.2011.04.014