Bligh, Annie Sim WanAnnie Sim WanBlighWardle, N. J.Hudson, H. R.Matthews, R. W.Nunn, C.Vella, C.2021-11-152021-11-152009https://repository.sfu.edu.hk/handle/sfu/1735Novel O,O-diethyl 1-benzamido-2,2-biscarbamoylethanephosphonates were synthesised as putative substrates to HIV-1 PR, to exploit the state of activation of the phosphonate electrophilic function in β-carboxamidophosphonate arrangements. O,O-Diethyl 1-benzamido-2,2-bis[(1S)-N-(1-benzyl-2-hydroxyethyl)carbamoyl]ethanephosphonate exhibited moderate anti-HIV activity in vitro (EC50 = 53 μrbamoyl]ethanephosphonate inhibited HIV-1 PR (IC50 = 31 μM).enjournal article10.2174/157018009787582660