Bligh, Annie Sim WanAnnie Sim WanBlighBashall, A.Garrud, C.McPartlin, M.Wardle, N.White, K.Padhye, S.Barve, V.Kundu, G.2021-12-102021-12-102003https://repository.sfu.edu.hk/handle/sfu/2030¹ H NMR and LC-ESI-MS studies of the interaction between nucleosides (adenosine, cytidine, guanosine, uridine and thymidine) and a monocation platinum(II) complex [Pt(<i>C</i>-(6-aminomethylpyridin-2-yl)methylamine)Cl]⁺ (<b>1</b>) shows it forms platinum(II) complexes with A, G and C at pH 6 and with T and U at pH 9. The X-ray structure of <b>1</b> as the hydrated chloride salt shows extensive hydrogen bonding. Amongst a series of related complexes <b>1</b> shows a strong interaction with DNA, demonstrated by inhibition of binding by the intercalator ethidium bromide, and moderate cytotoxicity. The interaction with nucleosides and the structural data suggest that <b>1</b> disrupts the DNA structure by coordinate covalent interaction and hydrogen bonding rather than simple intercalation.enjournal article10.1039/B208790A