Chan, Stella Sze WaStella Sze WaChanYamamoto, K.Rudd, J. A.Lin, G.Asano, K.Yamatodani, A.2023-06-192023-06-192009https://repository.sfu.edu.hk/handle/sfu/4048We investigated the effect of cisplatin on glutamate release in the hypothalamus of Suncus murinus measured by brain microdialysis. Dialysis samples were collected every 20 min for 1 h before and 3 h after the cisplatin (30 mg/kg, i.p.) administration with the animals also being observed for the development of emesis. Cisplatin increased glutamate levels within 1 h and this was closely associated with the occurrence of emesis. Pretreatment with the 5-HT₃– receptor antagonist ondansetron (2 mg/kg, i.p.) inhibited both the emesis and the increased glutamate levels. These results suggest that hypothalamic glutamate is involved in cisplatin-induced emesis in Suncus murinus.enjournal article10.1254/jphs.08333SC