Bligh, Annie Sim WanAnnie Sim WanBlighYang, L.Qin, L.-H.Bashall, A.Zhang, C.-F.Zhang, M.Wang, Z.-T.Xu, L.-S.2021-12-092021-12-092006https://repository.sfu.edu.hk/handle/sfu/2018Investigation of phenolic patterns from the stems of <i>Dendrobium chrysanthum</i> by HPLC–PDA–MS has led to the isolation of a new phenanthrene derivative with a spirolactone ring, dendrochrysanene (<b>1</b>), that proved to suppress the mRNA level of TNF-α, IL8, IL10, and iNOS in murine peritoneal macrophages. The structure of 1 was characterized on the basis of various NMR (<sup>1</sup>H, <sup>13</sup>C, <sup>1</sup>H–<sup>1</sup>H COSY, HMQC, and HMBC), mass spectrometry, and X-ray crystal diffraction data.enA new phenanthrene with a spirolactone from Dendrobium chrysanthum and its anti-inflammatory activitiesjournal article10.1016/j.bmc.2006.01.004