Self-assembled liposomes from amphiphilic electrospun nanofibers
Author(s)
Author(s)
Yu, D.-G.
Branford-White, C.
Williams, G. R.
White, K.
Zhu, L.-M.
Chatterton, N. P.
Date Issued
2011
Publisher
Royal Society of Chemistry
Journal
Soft Matter
Volume
7
Issue
18
Start page
8239
End page
8247
Abstract
Amphiphilic nanofibers composed of the hydrophilic polymer polyvinylpyrrolidone K60 (PVP) and soybean lecithin were fabricated using an electrospinning process. As a result of the templating and confinement properties of the nanofibers, phosphatidyl choline (PC) liposomes were spontaneously formed through molecular self-assembly when the fibers were added to water. The sizes of the self-assembled liposomes could be manipulated by varying the content of PC in the nanofibers (over the range 9.1–33.3% (w/w) in the present study). The influence of PC on nanofiber formation, and a possible mechanism of templated liposome formation are discussed. This facile and convenient strategy for manipulating molecular self-assembly to synthesize liposomes provides a versatile new approach for the development of novel drug delivery systems and biomaterials.
SFU Affiliated Publication
No
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