Synthesis and anti-cancer evaluation of cyclotriphosphazene hydrazone derivatives

Author(s)
Author(s)
Patil, B. R.
Machakanur, S. S.
Hunoor, R. S.
Badiger, D. S.
Gudasi, K. B.
Date Issued
2011
Publisher
Scholars Research Library
Journal
Der Pharma Chemica
Volume
3
Issue
4
Start page
377
End page
388
Abstract
Hexasubstituted cyclotriphosphazene hydrazones [N3P3(-OC6H4-p-CH=N-NH-C(O)-C6H4-p-X)6] were prepared by the reaction of hexachlorocyclotriphosphazene with N'-(4- hydroxybenzylidene)-4-substituted-benzohydrazides [HO-C6H4-p-CH=N-NH-C(O)-C6H4-p-X]. The structures were confirmed by elemental analysis, FT-IR, 1H, 13C, 31P NMR and mass spectrometry. These cyclic model systems bearing hydrolysable hydrazone linkages were evaluated for their antiproliferative activity in vitro against the human liver carcinoma cell line (HepG2) and Human cervix carcinoma cell line (HeLa).
URI
SFU Affiliated Publication
No
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