Preparation and characterization of medicated PAN/PVP composite fibers for better drug release profiles
Author(s)
Author(s)
Yu, D.-G.
Shen, X.-X.
Zhu, L.-M.
Branford-White, C.
Yang, Y. C.
Date Issued
2009
Publisher
IEEE
Related Publication(s)
2009 3rd International Conference on Bioinformatics and Biomedical Engineering (iCBBE) Proceedings
Start page
1011
End page
1014
Abstract
Fine and continuous composite medicated PAN/PVP fibers were prepared using wet spinning processes. The co-dissolving method was employed to prepare the spinning solution. The prepared fiberts had a diameter of 145 plusmn 17 mum. SEM images showed that the libers had a uniform and homogeneous structure with some nano drug particles aggregated on the fiber surface. X-ray diffraction analysis result suggested that ibuprofen existed in the fibers in an amorphous status. FTIR analysis result demonstrated the polymers and the drug had fine compatibility. The drug content in the fibers was found to be a little lower than that in the spinning liquid, 10.2% of the drug was lost during the spinning processes. In vitro dissolution tests indicated that composite medicated fibers had better release profiles than PAN medicated fibers, 84.2% of the incorporated ibuprofen was linearly released out during a time periods of 15 days.
SFU Affiliated Publication
No
Availability at SFU Library
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