ω-Phosphinyl-α-amino acids: Synthesis, and development towards use as therapeutic agents
Author(s)
Author(s)
Wardle, N. J.
Hudson, H. R.
Date Issued
2007
Publisher
Bentham Science
Journal
Current Organic Chemistry
Volume
11
Issue
18
Start page
1635
End page
1651
Abstract
Literature publications (up to September 2006) concerning the synthesis of ω-phosphinyl-α-amino acids and their development towards use as therapeutic agents are reviewed. General and asymmetric methodologies for the preparation of straight-chain examples are described, including AP3-7 modulators of glutamate-responsive excitatory amino acid (EAA) receptors (i.e. ionotropic NMDA-, and metabotropic GrpIII mGlu-receptors), and the glutamate synthetase inhibitor phosphinothricin. Focusing primarily on the development of methods for introducing phosphonate and aminocarboxylate functions to the appropriate scaffold, approaches to conformationally constrained ω-phosphinyl-α-amino acids are also investigated, along with their relevance to the development of therapeutic regimens towards neurodegenerative disorders.
SFU Affiliated Publication
No
Availability at SFU Library
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