Dimeric yttrium(iii) and neodymium(iii) macrocyclic complexes: Potential catalysts for hydrolysis of double-stranded DNA

Author(s)
Author(s)
Choi, N.
Evagorou, E. G.
McPartlin. M.
White, K. N.
Date Issued
2001
Publisher
Royal Society of Chemistry
Journal
Journal of the Chemical Society, Dalton Transactions
Issue
21
Start page
3169
End page
3172
Abstract
Dimeric complexes of macrocycle L, [{ML(OH)(H2O)}2](NO3)4 where M = Y and Nd, have been prepared via template synthesis. X-Ray structural analysis of [{YL(OH)(H2O)}2]4+ showed each yttrium atom to be coordinated to six nitrogens in the macrocycle, two hydroxide bridging units and one water molecule; the two macrocycles within the dimer have virtually identical conformations. Both dimeric complexes have the remarkable ability to degrade dsDNA, while the corresponding monomers have no activity. Cleavage likely involves random attack at single strands, in which closed circular plasmid DNA is initially converted to a nicked DNA intermediate before final cleavage.
URI
DOI
SFU Affiliated Publication
No
Availability at SFU Library

No database links found.