Metabolic dysfunction-associated profiles and subsequent site-specific risk of obesity-related cancers among Chinese patients with diabetes: A retrospective cohort study
Author(s)
Author(s)
Yau, S. T. Y.
Leung, E.
Wong, M. C. S.
Hung, C. T.
Chong K. C.
Yeoh, E. K.
Date Issued
2024
Publisher
BMJ
Journal
BMJ Open
Volume
14
Issue
4
Abstract
Objectives
To compare metabolic dysfunction-associated profiles between patients with diabetes who developed different obesity-related site-specific cancers and those who remained free of cancer during follow-up.
Design
Retrospective cohort study.
Setting
Public general outpatient clinics in Hong Kong.
Participants
Patients with diabetes without a history of malignancy (n=391 921).
Primary outcome measures
The outcomes of interest were diagnosis of site-specific cancers (colon and rectum, liver, pancreas, bladder, kidney and stomach) during follow-up. Cox proportional hazards regression was applied to assess the associations between metabolic dysfunction and other clinical factors with each site-specific cancer.
Results
Each 0.1 increase in waist-to-hip ratio was associated with an 11%–35% elevated risk of colorectal, bladder and liver cancers. Each 1% increase in glycated haemoglobin was linked to a 4%–9% higher risk of liver and pancreatic cancers. While low-density lipoprotein cholesterol and triglycerides were inversely associated with the risk of liver and pancreatic cancers, high-density lipoprotein cholesterol was negatively associated with pancreatic, gastric and kidney cancers, but positively associated with liver cancer. Furthermore, liver cirrhosis was linked to a 56% increased risk of pancreatic cancer. No significant association between hypertension and cancer risk was found.
Conclusions
Metabolic dysfunction-associated profiles contribute to different obesity-related cancer outcomes differentially among patients with diabetes. This study may provide evidence to help identify cancer prevention targets during routine diabetes care.
SFU Affiliated Publication
No
Availability at SFU Library
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