Gd(III) complexes intercalated into hydroxy double salts as potential MRI contrast agents
Author(s)
Author(s)
Jin, M.
Spillane, D. E. M.
Geraldes, C. F. G. C.
Williams, G. R.
Date Issued
2015
Publisher
Royal Society of Chemistry
Journal
Dalton Transactions
Volume
44
Issue
47
Start page
20728
End page
20734
Abstract
The ion exchange intercalation of two Gd-based magnetic resonance imaging contrast agents into hydroxy double salts (HDSs) is reported. The presence of Gd3+ diethylenetriaminepentaacetate and Gd3+ diethylenetriaminepenta(methylenephosphonate) complexes in the HDS lattice after intercalation was confirmed by microwave plasma-atomic emission spectroscopy. The structural aspects of the HDS-Gd composites were studied by X-ray diffraction, with the intercalates having an interlayer spacing of 14.5–18.6 Å. Infrared spectroscopy confirmed the presence of characteristic vibration peaks associated with the Gd3+ complexes in the intercalation compounds. The proton relaxivities of the Gd3+ complex-loaded composites were 2 to 5-fold higher in longitudinal relaxivity, and up to 10-fold higher in transverse relaxivity, compared to solutions of the pure complexes. These data demonstrate that the new composites reported here are potentially potent MRI contrast agents.
SFU Affiliated Publication
No
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